Jurnal Kedokteran Meditek

Profil Hemoglobin, Trombosit, dan Rasio Neutrofil Limfosit pada Pasien Kanker Kolorektal: Studi Deskriptif di RSUP Haji Adam Malik Medan

Ruth Vanessa Simatupang — 2025-10-06

Introduction: Colorectal cancer is a global health problem with an increasing incidence. Monitoring cancer stage is crucial as it is closely related to therapeutic decisions, prognosis, and patient survival. Simple hematological parameters, such as hemoglobin, platelet count, and neutrophil-to-lymphocyte ratio, may aid in clinical evaluation. Objective: This study aimed to describe the profiles of hemoglobin, platelet count, and neutrophil-to-lymphocyte ratio in patients with colorectal cancer. Methods: The study employed a descriptive observational method with a cross-sectional approach. Secondary data were obtained from the medical records of 141 patients using the total sampling method. Data analysis was performed using descriptive statistics. Results: Anemia was found in 83% of patients, with a higher incidence at higher stages. Normal platelet counts were observed in 80% of patients, with decreasing proportions in higher stages. Elevated NLR was found in 78% of patients and was more frequent at higher stages of disease. Conclusion: These findings indicate the presence of anemia and a systemic inflammatory response, but not thrombocytosis. This research highlights the potential of these simple biomarkers in monitoring cancer stages and treatment strategies.

Dari Lemak ke Sendi: Bahaya Proporsi Lemak Tubuh sebagai Penyebab Osteoartritis Lutut

Lyvia Ariella Kwok — 2025-10-09

Introduction: As individuals age, the incidence of osteoarthritis increases. Globally, it is reported that approximately 300 million individuals, particularly the elderly, are affected by osteoarthritis. Metabolic disorders related to lipid pathways have been associated with the development of osteoarthritis in the elderly. Purpose: This study aims to provide an overview of the relationship between haematological indicators, lipid profiles, and body fat proportion with osteoarthritis in the elderly population in Pusaka Kebon Jeruk, West Jakarta. Methods: This study used a cross-sectional design involving an elderly population, with 100 respondents aged ≥60 years who were willing to participate. Data were collected through interviews using an osteoarthritis questionnaire, blood draws, and measurements using BIA. The chi-square test (p<0.05) and multiple logistic regression (p<0.25) were used in this study. Results: Of the 100 respondents, it was found that 28% of the elderly respondents experienced osteoarthritis. Bivariate analysis showed a significant relationship between body fat proportion and osteoarthritis (p: 0.006; OR: 3.519; 95% CI: 1.394–8.878). Multivariate analysis indicated that body fat proportion was the dominant factor associated with osteoarthritis (p: 0.006; OR: 3.814; 95% CI: 1.475–9.865). Conclusions: We concluded that body fat proportion has a significant relationship with the incidence of osteoarthritis. However, this study did not find any significant associations between hemoglobin, white blood cells, RDW, LDL, HDL, triglycerides, and cholesterol.

Karakteristik Anak Penderita PJB dengan Pirau Kiri ke Kanan Disertai Pembesaran Ventrikel Kiri di RSPAL dr.Ramelan

Inggrid Fitria Maharani Subroto — 2025-09-26

Introduction: Congenital Heart Disease (CHD) is one of the most common congenital disabilities, with an incidence of 8-10 per 1000 live births in full-term infants and ten times higher in preterm infants. In Indonesia, the incidence of CHD is estimated at around 8 per 1000 live births. Understanding the anatomy and pathophysiology of the defect that occurs contributes to the accuracy of management planning. Purpose: This study aims to identify the characteristics of pediatric patients with CHD featuring left-to-right shunt accompanied by left ventricular enlargement at RSPAL dr. Ramelan Surabaya from 2020 to 2023. Methods: The descriptive study uses secondary data (medical records) of pediatric CHD patients with left-to-right shunt and left ventricular enlargement, specifically focusing on ventricular septal defect (VSD) and patent ductus arteriosus (PDA) at the pediatric clinic of RSPAL dr. Ramelan. Results: Based on medical records from 45 samples, the majority of CHD patients were aged 1-12 months (23 children). CHD with VSD was more common in males (18 children), while PDA was more common in females (11 children). Most CHD patients showed no initial complaints (39 children) and did not have other types of congenital heart diseases, with 23 children having VSD and 10 having PDA. Additionally, most patients did not have comorbidities (39 children). Echocardiographic results indicated that most patients had an ejection fraction (EF) greater than 75% (27 children) and a fractional shortening (FS) greater than 45% (23 children). The main management involved echocardiographic evaluation and medication. Conclusion: The predominant age group for CHD cases at the pediatric clinic of RSPAL dr. Ramelan was 1-12 months, with echocardiographic results showing normal left ventricular function, with EF >75% and FS >45%.

Susceptibility of Gastroesophageal Reflux Disease Symptoms in Medical Students: A Formative Study

Eviana Budiartanti Sutanto — 2025-10-11

Introduction: Gastroesophageal Reflux Disease (GERD) is a common chronic health problem associated with decreased quality of life and high morbidity. Many factors, including lifestyle, eating habits, medication, and mental stress, can trigger gastroesophageal reflux disease. A medical student who experiences high pressure during their training may have a GERD issue. Hence, this study aims to investigate the correlation between risk factors and the development of GERD in medical students. Methods: We used data from a cross-sectional study conducted at Soegijapranata Catholic University, Semarang, among medical students. Participants were recruited with inclusion criteria, namely all students aged over 18 years who were willing to fill out a questionnaire voluntarily, and were not undergoing treatment for gastric ulcers or mental disorders. Two questionnaires are used: a questionnaire developed to obtain demographic characteristics and a GERDQ questionnaire. A significant relationship is considered to occur if the p-value <0.05. Result: A total of 122 students were included. Among them, 23 students, consisting of 16 (13.11%) women and 7 (5.73%) men, suffered from GERD. It was found that nine people (7.4%) consumed NSAIDs, with a p-value of 0.014. Conclusion: The prevalence of GERD among medical students is relatively high, showing a significant link between the use of NSAIDs and GERD. Practical studies are needed to tackle the issue of uncontrolled NSAID use and to promote lifestyle modifications.

Profil HPV Genotyping dan Pap Smear LBC di MRCCC Siloam Hospitals Semanggi

Angeline Calista — 2025-09-26

Introduction: Cervical cancer is the second most common malignancy among Indonesian women after breast cancer, with 36,964 cases and 20,708 deaths in 2022. Cervical cancer screening studies using HPV genotyping and pap smear LBC have already been conducted in Indonesia using different methods. Purpose: The objectives of this study were to determine the HPV prevalence and genotype distribution, also the cytological results at MRCCC Siloam Hospitals Semanggi. Methods: A descriptive study with a cross-sectional design was conducted using 599 samples selected by consecutive non-random sampling from 2023–2024. HPV genotyping was performed using the DiagCor GenoFlow™ HPV array test, and pap smear analysis was conducted using PathTezt™ liquid-based cytology. Results: This study found 18.2% patients positive for HPV, comprising 58.7% with high-risk HPV only, 23% with low-risk HPV only, and 18.3% with mixed HPV infection Among all HPV-positive women, 53.2% had multiple HPV infections. The prevalence of high-risk HPV infection was 62.4%, with the most frequently detected genotypes were HPV-68, HPV-66, and HPV-52. The most frequent low-risk HPV infections were HPV-42, HPV-43, and HPV-44. Abnormal cytology results were found in 2.8% of patients, specifically ASC-US, LSIL, ASC-H, and AGC. Conclusion: The most prevalent HPV genotypes identified were HPV-68 (10.1%) and HPV-66 (9.6%). The study concludes that a positive HPV test is not always accompanied by abnormal cytology results. Therefore, HPV genotyping should be performed in conjunction with cytological examination for comprehensive screening.

Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS) Syndrome Associated with Liver Injury in Patient with Spondylarthritis: A Case Report

Eyleny Meisyah Fitri — 2025-10-06

Introduction: Drug reaction with eosinophilia and systemic symptoms syndrome or DReSS is a rare and life-threatening severe hypersensitivity reaction characterized by multiorgan involvement, with the liver as the common visceral manifestation. Approximately 10% of patients showed no changes in their eosinophil count. Sulfasalazine and non-steroidal anti-inflammatory drugs are frequently associated with DReSS. The diagnosis of this syndrome remains challenging due to the variety of clinical presentations. Case Illustration: We reported a 48-year-old woman who presented with pruritic generalized morbilliform eruption accompanied by facial edema and fever. Five weeks prior, she was treated with sulfasalazine and diclofenac sodium for spondyloarthritis. Her laboratory results showed elevated liver, suggesting drug-induced liver injury. DReSS syndrome was diagnosed by applying the European RegiSCAR. A favorable outcome and recovery of liver function are significantly seen after withdrawal of the suspected drugs, supportive treatment, and administration of systemic corticosteroid. Discussion: Sulfasalazine was one of the drugs frequently reported to cause DReSS syndrome. Liver involvement ranges from reversible elevation of liver function tests to hepatic necrosis. Withdrawal of causative drugs and administration of methylprednisolone were recommended, particularly for DReSS with liver involvement. Conclusions: DReSS syndrome can manifest with typical skin lesions and multiorgan involvement despite the absence of eosinophilia. The leading cause of mortality related to acute liver injury ranges from mild transaminase to acute liver failure. Prompt cessation of the culprit drug, immunosuppressive therapy, and a multidisciplinary approach might prevent further complications and mortality.

Severe Leptospirosis (Weil’s Disease) Complicated by Septic Shock: A Case Report

Melvin Andrean — 2025-10-11

Introduction: Weil’s disease is the severe manifestation of leptospirosis, characterized by multiorgan dysfunction and high mortality risk without timely diagnosis and treatment. Early clinical suspicion and prompt intervention are critical for favorable outcomes. Case Illustration: a 51-year-old male with fever, left leg myalgia, jaundice, hypotension, and tachycardia consistent with septic shock. Laboratory evaluation revealed leukocytosis, acute liver injury, and severe acute kidney injury. Additionally, chest imaging revealed bilateral pulmonary infiltrates. Initial management included fluid resuscitation, vasopressors, and broad-spectrum antibiotics. Leptospira IgM serology confirmed the presence of leptospirosis on day 2. Despite severe acute kidney injury, renal function improved without dialysis, and vasopressors were discontinued by day 3. The patient was discharged on day 11, having made a full recovery. Discussion: Severe leptospirosis can present with nonspecific symptoms and progress to septic shock and multiorgan dysfunction. In this case, the diagnosis was supported by IgM-ELISA and a history of exposure to floodwater. Early treatment with broad-spectrum antibiotics and supportive care led to a full recovery. Conclusion: This case highlights the uncommon presentation of septic shock as the dominant feature of Weil’s disease, together with rapid renal recovery without dialysis, underscoring the reversibility of multiorgan dysfunction when promptly managed.