Susceptibility of Gastroesophageal Reflux Disease Symptoms in Medical Students: A Formative Study

Authors

  • Eviana Budiartanti Sutanto Faculty of Medicine, Soegijapranata Catholic University, Semarang, Indonesia
  • Luciana Budiati Sutanto Faculty of Medicine and Health Sciences, Krida Wacana Christian University, Jakarta, Indonesia
  • Fransisca Pramesshinta Hardimarta Faculty of Medicine, Soegijapranata Catholic University, Semarang, Indonesia
  • Henrita Ernestia Faculty of Medicine, Soegijapranata Catholic University, Semarang, Indonesia
  • Lidwina Indra Aprilia Christiana To Faculty of Medicine, Soegijapranata Catholic University, Semarang, Indonesia
  • Cynthia Tjitradinata Faculty of Medicine, Soegijapranata Catholic University, Semarang, Indonesia
  • Perigrinus Hermin Sebong Faculty of Medicine, Soegijapranata Catholic University, Semarang, Indonesia

DOI:

https://doi.org/10.36452/jkdoktmeditek.v31i5.3758

Keywords:

Formative study, GERD, Medical Students, NSAID

Abstract

Introduction: Gastroesophageal Reflux Disease (GERD) is a common chronic health problem associated with decreased quality of life and high morbidity. Many factors, including lifestyle, eating habits, medication, and mental stress, can trigger gastroesophageal reflux disease. A medical student who experiences high pressure during their training may have a GERD issue. Hence, this study aims to investigate the correlation between risk factors and the development of GERD in medical students. Methods: We used data from a cross-sectional study conducted at Soegijapranata Catholic University, Semarang, among medical students. Participants were recruited with inclusion criteria, namely all students aged over 18 years who were willing to fill out a questionnaire voluntarily, and were not undergoing treatment for gastric ulcers or mental disorders. Two questionnaires are used: a questionnaire developed to obtain demographic characteristics and a GERDQ questionnaire. A significant relationship is considered to occur if the p-value <0.05. Result: A total of 122 students were included. Among them, 23 students, consisting of 16 (13.11%) women and 7 (5.73%) men, suffered from GERD. It was found that nine people (7.4%) consumed NSAIDs, with a p-value of 0.014. Conclusion: The prevalence of GERD among medical students is relatively high, showing a significant link between the use of NSAIDs and GERD. Practical studies are needed to tackle the issue of uncontrolled NSAID use and to promote lifestyle modifications.

References

Clarrett DM, Hachem C. Gastroesophageal reflux disease (GERD). Mo. Med. 2018;115:214–8. PMID: 30228725. [cited 2025 Jan 10]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6140167/

Antunes C, Aleem A, Curtis SA. Gastroesophageal reflux disease. StatPearls. Treasure Isl. StatPearls Publ.2025. PMID: 28722967. [cited 2025 Jan 10]. Available from: https://pubmed.ncbi.nlm.nih.gov/28722967/

Azer SA, Goosenberg E. Gastroesophageal Reflux Disease. StatPearls. Treasure Isl. StatPearls Publ. 2025. [cited 2025 Jan 10]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554462/.

Syam AF, Hapsari PF, Makmun D. The Prevalence and Risk Factors of GERD among Indonesian Medical Doctors. Makara J. Heal. Res. 2016; 20(2):35-40. [cited 2025 Jan 10]. Available from: https://doi.org/10.7454/msk.v20i2.5740.

Kahrilas J Peter. Clinical manifestations and diagnosis of gastroesophageal reflux in adults. UpToDate. 2020.[cited 2025 Jan 11]. Available from: https://www.uptodate.cn/contents/initial-management-of-gastroesophageal-reflux-disease-in-adults

Al Ghadeer HA, Alabbad ZE, AlShaikh SB, et al. Prevalence of Gastroesophageal Reflux Disease and Associated Risk Factors in the Eastern Region, Saudi Arabia. Cureus. 2021;13:4–11. [cited 2025 Jan 10]. Available from:https://doi.org/10.7759/cureus.19599.

Sadafi S, Azizi A, Pasdar Y, Shakiba E, Darbandi M. Risk factors for gastroesophageal reflux disease: a population-based study. BMC Gastroenterol. 2024;24:1–7. [cited 2025 Jan 12] Available from: https://doi.org/10.1186/s12876-024-03143-9.

Kim O, Jang HJ, Kim S, et al. Gastroesophageal reflux disease and its related factors among women of reproductive age: Korea Nurses’ Health Study. BMC Public Health. 2018;18:1–8. [cited 2025 Jan 10]. Available from: https://doi.org/10.1186/s12889-018-6031-3.

Saavedra JM, Lefferts EC, Song BK, Lee DC. The associations of daily steps and body mass index with incident gastroesophageal reflux disease in older adults. Front. Sport. Act. Living. 2024;6. [cited 2025 Jan 15]. Available from: https://doi.org/10.3389/fspor.2024.1384845.

Vaezi MF. GERD and obesity: A real big issue! Gastroenterology. 2008;134: 882–90. [cited 2025 Jan 10]. Available from: https://doi.org/10.1053/j.gastro.2008.01.049.

Zhang M, Hou ZK, Huang ZB, Chen XL, Liu FB. Dietary and lifestyle factors related to gastroesophageal reflux disease: A systematic review. Ther. Clin. Risk Manag. 2021;17:305–23. [cited 2025 Jan 15]. Available from: https://doi.org/10.2147/tcrm.s296680.

Çela L, Kraja B, Hoti K, et al. Lifestyle characteristics and gastroesophageal reflux disease: A population-based study in Albania. Gastroenterol. Res. Pract. 2013:936792. [cited 2025 Jan 15]. Available from: https://doi.org/10.1155/2013/936792.

Herdiana, Y. Functional Food in Relation to Gastroesophageal Reflux Disease (GERD). Nutrients. 2023;15:3583. [cited 2025 Jan 23]. Available from: https://doi.org/10.3390/nu15163583.

Choe JW, Joo MK, Kim HJ, et al. Foods inducing typical gastroesophageal reflux disease symptoms in Korea. J. Neurogastroenterol. Motil.2017;23:363–9. [cited 2025 Jan 15]. Available from: https://doi.org/10.5056/jnm16122.

Gurges P, Murray BJ, Boulos MI. Relationship between gastroesophageal reflux disease and objective sleep quality. J. Clin. Sleep Med. 2022;18:2731–8. [cited 2025 Jan 23]. Available from: https://doi.org/10.5664/jcsm.10198.

Sharma A, Sharma PK, Puri P. Prevalence and the risk factors of gastro-esophageal reflux disease in medical students. Med. J. Armed Forces India. 2018;74: 250–4. [cited 2025 Jan 15]. Available from: https://doi.org/10.1016/j.mjafi.2017.08.005.

Mu’taz M, Elhammouri N, Al-Zoubi N, et al. Gastroesophageal reflux disease in medical students: a cross-sectional study. Gastroenterol. Rev. 2024;19:303–10. [cited 2025 Jan 13]. Available from: https://doi.org/10.5114/pg.2024.143155.

Essa A, Nasser A, Noureldeen IM, et al. Gastroesophageal reflux disease among undergraduate medical students in Egypt: Prevalence and risk factors. Int. J. Gen. Med. 2024;17:6037–46. [cited 2025 Jan 23]. Available from: https://doi.org/10.2147/ijgm.s503049.

Baklola M, Terra M, Badr A, et al. Prevalence of gastro-oesophageal reflux disease, and its associated risk factors among medical students: a nation-based cross-sectional study. BMC Gastroenterol. 2023;23:1–7. [cited 2025 Jan 23]. Available from: https://doi.org/10.1186/s12876-023-02899-w.

Zaidan M, Al-Hawash S, Abu Farsakh NA, Khairallah K. Gastro-esophageal reflux disease (GERD) among medical students during COVID-19 pandemic. JAP Acad. J. 2023;1: 1–10. [cited 2025 Jan 23]. Available from: https://doi.org/10.58877/japaj.v1i1.6.

Weir CB, Jan A. BMI Classification Percentile and Cut Off Points. StatPearls Publishing. Treasure Isl. StatPearls Publ. 2021: 1-5. [cited 2025 Jan 10]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK541070.

Simadibrata M, Rani A, Adi P, Djumhana A, Abdullah M. The gastro-esophageal reflux disease questionnaire using indonesian language: A language validation survey. Med. J. Indones. 2011;20:125–30. [cited 2025 Jan 10]. Available from: https://doi.org/10.13181/mji.v20i2.442.

Sohail R, Mathew M, Patel KK, et al. Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review. Cureus. 2023;15:1–14. [cited 2025 Mar 20]. Available from: https://doi.org/10.7759/cureus.37080.

Mungan Z, Şimşek BP. Which drugs are risk factors for the development of gastroesophageal reflux disease?. Turkish J. Gastroenterol. 2017;28:S38–43. [cited 2025 Mar 20]. Available from: https://doi.org/10.5152/tjg.2017.11.

Aboalrob AI, Eid FM, Esa SM, et al. Prevalence, awareness, and patterns of non-steroidal anti-inflammatory drug use among health science students in Palestine: a cross-sectional study. Sci. Rep. 2023;13:19844. [cited 2025 Mar 20]. Available from: https://doi.org/10.1038/s41598-023-47279-2.

Kim SY, Jung HK, Lim J, et al. Gender specific differences in prevalence and risk factors for gastro-esophageal reflux disease. J. Korean Med. Sci. 2019;34:1–15. [cited 2025 Mar 20] Available from: https://doi.org/10.3346/jkms.2019.34.e158.

Scheese D, Chehab M, Puig CA. Sex Differences in Gastroesophageal Reflux Disease (GERD). Foregut J. Am. Foregut Soc. 2023;3:192–8. [cited 2025 Mar 20] Available from: https://doi.org/10.1177/26345161231166136.

Sharara AI, Rustom LBO, Daher HB, et al. Prevalence of gastroesophageal reflux and risk factors for erosive esophagitis in obese patients considered for bariatric surgery. Dig. Liver Dis. 2019;51:1375–9. [cited 2025 Mar 23]. Available from: https://doi.org/10.1016/j.dld.2019.04.010.

Xie M, Deng L, Fass R, Song G. Obesity is associated with higher prevalence of gastroesophageal reflux disease and reflux related complications: A global healthcare database study. Neurogastroenterol. Motil. 2024;36(4):14750. [cited 2025 Mar 23]. Available from: https://doi.org/10.1111/nmo.14750.

Kim KJ, Lee BS. Central obesity as a risk factor for non-erosive reflux disease. Yonsei Med. J. 2017;58:743–8. [cited 2025 Mar 27]. Available from: https://doi.org/10.3349/ymj.2017.58.4.743.

Wei TY, Hsueh PH, Wen SH, Chen CL, Wang CC. The role of tea and coffee in the development of gastroesophageal reflux disease. Tzu Chi Med. J. 2019;31:169–76. [cited 2025 Mar 27]. Available from: https://doi.org/10.4103/tcmj.tcmj_48_18.

Castaldo L, Toriello M, Sessa R, et al. Antioxidant and anti-inflammatory activity of coffee brew evaluated after simulated gastrointestinal digestion. Nutrients. 2021;13(12):4368. [cited 2025 Mar 20]. Available from: https://doi.org/10.3390/nu13124368.

Castaldo L, Izzo L, Narvaes A, et al. Colon bioaccessibility under in vitro gastrointestinal digestion of different coffee brews chemically profiled through UHPLC-Q-orbitrap HRMS. Foods. 2021;10(1):179. [cited 2025 Mar 27]. Available from: https://doi.org/10.3390/foods10010179.

Polese B, Izzo L, Mancino N, et al. Effect of Dewaxed Coffee on Gastroesophageal Symptoms in Patients with GERD: A Randomized Pilot Study. Nutrients. 2022;14(12):2510. [cited 2025 Mar 27]. Available from: https://doi.org/10.3390/nu14122510.

Nehlig A. Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update. Nutrients. 2022;14:1–31. [cited 2025 Mar 28]. https://doi.org/10.3390/nu14020399.

Zein AFMZ, Nauphar D, Khasanah U, et al. The Association Between the Pattern of Electronic Cigarette Smoking and Gastroesophageal Reflux. Indones. J. Gastroenterol. Hepatol. Dig. Endosc. 2021;22:16–20. [cited 2025 Mar 28]. Available from: https://doi.org/10.24871/221202116-20.

Yuan LZ, Yi P, Wang GS, et al. Lifestyle intervention for gastroesophageal reflux disease: a national multicenter survey of lifestyle factor effects on gastroesophageal reflux disease in China. Ther. Adv. Gastroenterol. Orig. Gastroenterol. Orig. 2019;12:1–12. [cited 2025 Mar 28]. Available from: https://doi.org/10.1177/1756284819877788.

Downloads

Published

2025-10-11

How to Cite

Sutanto, E. B., Sutanto, L. B. ., Hardimarta, F. P. ., Ernestia , H. ., To , L. I. A. C. ., Tjitradinata , C. ., & Sebong , P. H. . (2025). Susceptibility of Gastroesophageal Reflux Disease Symptoms in Medical Students: A Formative Study. Jurnal Kedokteran Meditek, 31(5). https://doi.org/10.36452/jkdoktmeditek.v31i5.3758

Issue

Section

Artikel Penelitian