Kadar 25(OH)D pada Pasien Lupus Eritematosus Sistemik di Indonesia

Kereun Yobelium Witan; Elli Arsita; Todung Donald Aposan Silalahi

doi:10.36452/jkdoktmeditek.v28i2.2267

Authors

Kereun Yobelium Witan Fakutas Kedokteran dan Ilmu Kesehatan, Universitas Kristen Krida Wacana, Jakarta, Indonesia
Elli Arsita Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Kristen Krida Wacana, Jakarta, Indonesia
Todung Donald Aposan Silalahi Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Kristen Krida Wacana, Jakarta, Indonesia

DOI:

https://doi.org/10.36452/jkdoktmeditek.v28i2.2267

Keywords:

defisiensi vitamin D, Indonesia, lupus eritematosus sistemik

Abstract

Vitamin D memiliki peran dalam sistem kekebalan tubuh, terutama sistem imun adaptif dalam toleransi diri dan menghasilkan antibodi pada pasien dengan autoimun. Defisiensi vitamin D merupakan hal yang sering ditemukan pada pasien Lupus Eritematosus Sistemik (LES). Hal ini dapat dikarenakan pantangan terhadap paparan sinar matahari, insufisiensi ginjal, penggunaan obat–obatan yang menurunkan regulasi reseptor vitamin D, dan penggunaan sunscreen. Tujuan penulisan ilmiah ini adalah untuk mengetahui kadar vitamin D pada pasien LES di Indonesia. Data didapatkan dari jurnal penelitian yang diambil melalui Google Scholar, Proquest, Pubmed, dan Science Direct. Hasil pencarian didapatkan 4 artikel yang mengambil lokasi penelitian di Malang, 2 artikel di Jakarta, dan 1 artikel di Yogyakarta. Simpulannya adalah bahwa 63,74% pasien LES di Indonesia memiliki defisiensi kadar vitamin D yang disebabkan oleh kurangnya paparan sinar matahari, warna kulit, penggunaan sunblock, memiliki manifestasi klinis nefritis, penggunaan obat–obatan (kortikosteroid dan anti malaria), Indeks Masa Tubuh (IMT) di atas normal, kurangnya konsumsi makanan yang mengandung vitamin D, dan konsumsi suplemen vitamin D yang tidak adekuat.

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