Perkembangan Terkini Terapi Sistemik Psoriasis

Authors

  • Natalia Rania Sutanto Departemen Dermatologi dan Venereologi Fakultas Kedokteran Universitas Indonesia/RSPN dr. Cipto Mangunkusumo, Jakarta, Indonesia
  • Windy Keumala Budianti Departemen Dermatologi dan Venereologi, Fakultas Kedokteran Universitas Indonesia/RSUPN dr. Cipto Mangunkusumo, Jakarta

DOI:

https://doi.org/10.36452/jkdoktmeditek.v27i2.2043

Keywords:

biosimilar, obat biologik, psoriasis, small molecules, terapi sistemik

Abstract

Psoriasis merupakan penyakit inflamasi kulit akibat aktivasi terhadap sistem imun bawaan dan adaptif. Etiopatogenesis psoriasis merupakan proses kompleks dan multifaktorial, yang dipengaruhi oleh faktor genetik dan lingkungan seperti stres, trauma, dan infeksi. Pada pasien dengan psoriasis kategori sedang hingga berat dan lesi lokalisata di area skalp, wajah, kuku, telapak tangan dan kaki, serta genital merupakan indikasi untuk pemberian terapi dengan obat sistemik. Saat ini terdapat berbagai pilihan terapi sistemik yang tersedia yaitu obat sistemik konvensional, terapi small molecules, obat biologik, dan biosimilarnya yang terdiri atas inhibitor TNF-α, inhibitor IL-12/23, inhibitor IL-17, dan inhibitor IL-23. Selama dekade terakhir, tata laksana psoriasis telah mengalami pergeseran paradigma yaitu obat biologik dan biosimilarnya mulai menjadi pilihan utama karena telah terbukti memiliki efikasi yang lebih kuat dengan efek samping minimal. Tinjauan pustaka ini membahas perkembangan terapi sistemik psoriasis terkini sehingga diharapkan dapat memberikan acuan untuk memilih terapi yang tepat, efektif, dan aman untuk pasien psoriasis.

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Published

2021-06-25 — Updated on 2021-06-25

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How to Cite

Sutanto, N. R., & Budianti, W. K. (2021). Perkembangan Terkini Terapi Sistemik Psoriasis. Jurnal Kedokteran Meditek, 27(2), 136–146. https://doi.org/10.36452/jkdoktmeditek.v27i2.2043

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Section

Tinjauan Pustaka