Peranan Asam Klorogenat Tanaman Kopi Terhadap Penurunan Kadar Asam Urat dan Beban Oksidatif
DOI:
https://doi.org/10.36452/jkdoktmeditek.v25i1.1758Keywords:
kafein, asam klorogenat, kopi, kadar asam uratAbstract
Tanaman kopi termasuk dalam golongan familia Rubiaceae, merupakan tumbuhan tropis yang tumbuh di lereng gunung. Selain mengandung senyawa kafein, kopi juga mengandung polifenol yang sangat tinggi, yaitu dalam bentuk caffeoylquinic acids (CQAs), feruloylquinic acids (FQAs), dan dicaffe oylquinic acids (diCQAs) serta asam klorogenat (chlorogenic acid). Di antara senyawa polifenol tersebut, yang paling banyak terdapat di dalam kopi adalah asam klorogenat. Kandungan asam klorogenat dalam kopi Robusta sekitar 7,0–10,0 % dan dalam biji kopi Arabika adalah 7,73 %. Senyawa ini memiliki efek farmakologi sebagai antioksidan, sehingga dapat menurunkan beban oksidatif dalam tubuh, dan memiliki kemampuan menghambat aktivitas enzim xantin oksidase, sehingga dapat menurunkan kadar asam urat dalam darah penderita hiperurisemia.
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21. Belay, Abebe, Gholap AV. Characterization and determination of chlorogenic acids (CGA) in coffee beans by UV-Vis spectroscopy. African J of Pure and Applied Chemistry. 2009;3(11): 234-40.
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24. Grotto D, Maria L, Valentini J, Paniz C, Schmitt G, Garcia S et al. Importance of the lipid peroxidation biomarkers and methodological aspects for malondialdehyde quantification. Química Nova. 2009;32(1):169-74.
2. Ayelign A, Sabally K. Determination of chlorogenic acids (CGA) in coffee beans using HPLC. Department of Post Harvest Management College of Agriculture and Veterinary Medicine Jimma University Ethiopia. 2013. hlm. 3-4.
3. Lelyana R. Pengaruh kopi terhadap kadar asam urat darah. Semarang : Program Pascasarjana Magister Ilmu Biomedik Universitas Diponegoro; 2008. Tesis.
4. Alam N, Yoon KN, Lee KR, Kim HY, Shin PG, Cheong JC, et al. Assessment of antioxydant and phenolic compound concentration as well as xanthine oxidase and tyrosinase inhibitory properties of different extracts of pleurotus citrinopileatus fruiting bodies. Mycobiology 2011;39(1). (diunduh 25 Mar 2017). Tersedia dari: http://www.ncbi.nlm. nih.gov/pmc/articles/PMC3385085/.
5. Koto FA, Kadri H, Rofinda ẐD. Pengaruh pemberian kopi instan oral terhadap kadar asam urat pada tikus wistar. Jurnal Kesehatan Andalas. 2014;3(3).
6. Farhaty N, Muchtaridi. Tinjauan kimia dan aspek farmakologi senyawa asam klorogenat pada biji kopi. Jurnal Farmaka Fakultas Farmasi Universitas Padjadjaran. 2014;4(1).
7. Putra TR. Hiperurisemia. Dalam: Setiati S, Sudoyo AW, Setiyohadi B, Simadibrata M, Syam AF, editor. Buku ajar ilmu penyakit dalam, Jilid III Edisi ke-V. Jakarta: Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia; 2009. Halaman?
8. Meguro S, Hasumura T, Hase T. Coffeepolyphenols exert hypocholesterolemiceffects in zebrafish fed a high-cholesteroldiet. Nutr Metab. 2013 [diunduh 19 Jan 2018]. Tersedia dari: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC 3871761/.
9. Kiyohara C, Kono S, Honjo S, Todoroki I, Sakurai Y, Nishiwaki M, et al. Inverse association between coffee drinking and serum uric acid concentrations in middle-aged Japanese males. Br J Nutr. 1999 [diunduh 19 Mar 2017]. Tersedia dari: http://www.ncbi.nlm.nih. gov/pubmed/10743484.
10. Mangiwa S, Futwembun A, Awak PM. Kadar asam klorogenat (CGA) dalam biji kopi arabika (Coffea Arabica) asal Wamena, Papua. Jurnal Ilmiah Pendidikan Kimia ‘Hidrogen’ 2015;3(2):313-7.
11. Tamakoshi A, Lin Y, Kawado M, Yagyu K, Kikuchi S, Iso H. Effect of coffee consumption on all-cause and total cancer mortality: Findings from the JACC study. European Journal of Epidemiology, 2011;26(4):285–93. [diunduh 20 Jul 2019]. Tersedia dari: https://doi.org/10.1007/s10654-011-9548-7
12. Kaplan M. Norman, weber A. Michael. Hypertension essentials. 2nd Ed. United States of America: Jones & Barlett Publishers; 2010. P.2 – 95.
13. Mesas AE, Leon M, Rodrigues A, Lopez G; The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis. Am J Clin Nutr. 2011 Oct;94(4):1113-26.
14. Wierzejska R. Coffe cosumption and cardiovascular disease – Has the times comes to change dietary advice? A mini review.Pol. J. Food Nutr. Sci. 2016;66(1):5–10.
15. Dewajanti AM, Sumbayak EM, Neno MA. Uji aktivitas antioksidan infusa biji kopi arabika (Coffea arabica L): pengukuran kadar malondialdehid (MDA) pada tikus wistar (Rattus novergicus) hiperurisemia. J Kedokt Meditek 2018;25(64).
16. Murray RK, Granner DK, Mayer PA, Rodwell VM. Biokimia Harper edisi 29 Jakarta : Penerbit Buku Kedokteran EGC; 2014.
17. Crozier A, Clifford MN, Ashihara A. Plant secondary metabolites: occurrence, structure and role in the human diet. Oxford: Blackwell Publishing, 2006.
18. Monteiro, Mariana, Farah A, Perrone D, Luiz C. Trugo, Donangelo C. Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans. The J of Nutrition. 2007;137: 2198-2201.
19. Farah, Adriana, Tomas De P, Daniel PM, Luiz CT, Peter RM. Chlorogenic acids and lactones in regular and water-decaffeinated arabica coffees. J Agric. FoodChem. 2006; 54(2): 374-81.
20. Ayelign, Abebe dan Kebba S. Determination of chlorogenic acid. Am J of Research Communication. 2013;1(2):78-91.
21. Belay, Abebe, Gholap AV. Characterization and determination of chlorogenic acids (CGA) in coffee beans by UV-Vis spectroscopy. African J of Pure and Applied Chemistry. 2009;3(11): 234-40.
22. Edward NL. Management of hyperuricaemia. Dalam: Koopman WJ, editor. Arthritis and allied condition: a textbook of rheumatology 14th ed. Philadelphia: Lippicott Williams & Wilkins Baltimore Publishing; 2001.
23. Kelly WN, Wortmann RL. Crystal-associated synovitis: gout and hyperuricemia 5th ed. Philadelphia: WB Saunders; 1997.
24. Grotto D, Maria L, Valentini J, Paniz C, Schmitt G, Garcia S et al. Importance of the lipid peroxidation biomarkers and methodological aspects for malondialdehyde quantification. Química Nova. 2009;32(1):169-74.
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Published
2019-09-04
How to Cite
Dewajanti, A. M. (2019). Peranan Asam Klorogenat Tanaman Kopi Terhadap Penurunan Kadar Asam Urat dan Beban Oksidatif. Jurnal Kedokteran Meditek, 25(1), 46–51. https://doi.org/10.36452/jkdoktmeditek.v25i1.1758
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