Efektivitas Immunoterapi Dalam Tatalaksana Guillain-Barré Syndrome Pada Anak
DOI:
https://doi.org/10.36452/jkdoktmeditek.v25i3.1783Kata Kunci:
autoimun, sistem saraf perifer, imunoterapi, imunoglobulin, GBSAbstrak
Guillain-Barré Syndrome (GBS) merupakan suatu kelainan mediator imun dari sistem saraf perifer dimana respon autoimun menjadi aktif dan menargetkan saraf perifer. Patogenesis GBS dipercaya sebagai sebuah respon imun yang abnormal terhadap sebuah kejadian yang terjadi sebelumnya, paling sering didahului oleh suatu infeksi, dan pada sebagian kecil kasus dilaporkan pasca imunisasi terutama untuk pasien anak-anak. Manifestasi klinis GBS berupa kelemahan ekstremitas bilateral progresif yang cepat dan bersifat ascending. Terapi yang masih digunakan dan dianggap efektif untuk saat ini yaitu immunoglobulin intravena (IVIg), dan plasmaferesis. Modalitas terapi baru seperti Interferon-β (IFN-β), Siklofosfamid, dan antibodi monoklonal manusia masih memerlukan penelitian lebih lanjut terkait efektivitas dan efek samping yang bisa terjadi. Prognosis GBS anak didapatkan lebih baik, mortalitas juga ditemukan lebih rendah yaitu sekitar 1-2% pada anak dengan GBS, dan hanya 4% dari seluruh pasien anak yang membutuhkan alat bantu pernapasan selama perawatan.
Referensi
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2. Rosen BA. Guillain-Barré Syndrome. Pediatrics in Review. 2012;33(4):164-70. doi:10.1542/pir.33-4-164.
1. Gopalakrishna KN, Ramesh VJ. Management of guillain-barré syndrome. J Neuroanaesthesiol Crit Care. 2019;6:160-6. doi:10.1055/s-0039-1688896.
2. Rosen BA. Guillain-Barré syndrome. Pediatrics in Review. 2012;33(4):164-70. doi:10.1542/pir.33-4-164.
3. Lawn ND, Fletcher DD, Henderson RD, Wolter TD, Wijddicks EF. Anticipating mechanical ventilation in guillain-barré syndrome. Arch Neurol. 2001;58(6):893-8. doi:10.1001/archneur.58.6.893.
4. Berg BV, Walgaard C, Drenthen J, Fokke C, Jacobs BC, Doorn PA. Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol. 2014;10:469-82. doi: 10.1038/nrneurol.2014.121.
5. Yuki N, Hartung HP. Guillain–Barré syndrome. N Engl J Med. 2012;366:2294–304. doi: 10.1056/NEJMra1114525.
6. Tam CC, Rodrigues LC, Petersen I, Islam A, Hayward A, O’Brien SJ. Incidence of Guillain–Barré syndrome among patients with campylobacter infection: a general practice research database study. J Infect Dis. 2006;194:95–7. doi: 10.1086/504294.
7. Goodfellow JA, Willison HJ. Guillain-Barré syndrome: a century of progress. Nat Rev Neurol. 2016;12(12):723–31. doi: 10.1038/nrneurol.2016.172.
8. Willison HJ, Jacobs BC, Doorn PA. Guillain-Barré syndrome. Lancet. 2016;388:717-27. doi: 10.1016/S0140-6736(16)00339-1.
9. Fokke C, Berg BV, Drenthen J, Walgaard C, Doorn PA, Jacobs BC. Diagnosis of Guillain-Barré syndrome and validation of brighton criteria. Brain. 2014;137:33-43.doi:10.1093/brain/awt285.
10. Sejvar JJ, Kohl KS, Gidudu J, Amato A, Bakshi N, Baxter R, et al. Guillain-Barre Syndrome and fisher syndrome: Case definitions and guidelines for collection, analysis, and presentation of immunization safety data. Vaccine. 2011;29:599-612.
11. Agrawal S, Peake D, Whitehouse WP. Management of children with Guillain-Barré syndrome. Arch Dis Child Educ Pract Ed. 2007;92(6):161-8. doi:10.1136/adc.2004.065706.
12. Lukito V, Mangunatmadja I, Pudjiadi AH, Puspandjono TM. Plasmaferesis sebagai terapi sindrom Guillain Barré berat pada anak. Sari Pediatri. 2010;11(6):450-1. doi: 10.14238/sp11.6.2010.448-55.
13. Alboudi AM, Sarathchandran P, Geblawi SS, Kayed DM, Inshasi J, Purayil SP, et al. Rescue treatment in patients with poorly responsive Guillain-Barré Syndrome. Sage Open Medicine. 2019;(7):1-5. doi: 10.1177/2050312119840195.
14. Verboon C, Doom PA, Jacobs BC. Treatment dilemmas in Guillain-Barré syndrome. J Neurol Neurosurg Psychiatry. 2016;88(4):346-52. doi:10.1136/jnnp-2016-314862.
15. Korinthenberg R, Schessl J, Kirschner J, Monting JS. Intravenously administered immunoglobulin in the treatment of childhood Guillain-Barré syndrome: a randomized trial. Pediatrics. 2005;116(1):8-14. doi: 10.1542/peds.2004-1324.
16. El-Bayoumi MA, El-Refaey AM, Abdelkader AM, El-Assmy MM, Alwakeel AA, El-Tahan HM. Comparison of intravenous immunoglobulin and plasma exchange in treatment of mechanically ventilated children with Guillain-Barré syndrome: a randomized study. Crit Care. 2011;15(4):R164. doi:10.1186/cc10305.
17. Kamate M, Detroja M, Reddy AN. Do all children with Guillain-Barre syndrome need immunotherapy? The Indian J of Ped. 2019. Doi: 10.1007/s12098-019-02864-0
18. Ortiz-Corredor F, Pena Preciado M. Use of immunoglobulin in severe childhood Guillain-Barre syndrome. Acta Neurol Scand. 2007;115:289-93. doi: 10.1111/j.1600-0404.2006.00766.x
19. Restrepo-Jimenez P, Rodríguez Y, González P, Chang C, Gershwin ME, Anaya JM. The immunotherapy of Guillain-Barré syndrome. Expert Opin Biol Ther. 2018;18(6):619-31. doi: 10.1080/14712598.2018.1468885.
20. Xiao J, Simard AR, Shi FD, Hao J. New strategies in the management of Guillain Barré syndrome. Clin Rev Allergy Immunol. 2014;47(3):274-88. doi: 10.1007/s12016-013-8388-5.
21. Lee JH, Sung IY, Rew IS. Clinical Presentation and prognosis of childhood Guillain Barre syndrome. J of Paed and Chil Health. 2008;44:449-54. doi : 10.1111/j.1440-1754.2008.01325.x
22. Korinthenberg R, Schessl J, Kirschner J. Clinical presentation and course of childhood Guillain Barré syndrome: a prospective multicentre study. Neuropediatrics. 2007;38(1):10-7. doi:10.1055/s-2007-981686
23. Vajsar J, Fehlings D, Stephens D. Longterm outcome in children with Guillain Barré syndrome. J Pediatr. 2003;142(3):305-9. doi: 10.1067/mpd.2003.115.
2. Rosen BA. Guillain-Barré Syndrome. Pediatrics in Review. 2012;33(4):164-70. doi:10.1542/pir.33-4-164.
1. Gopalakrishna KN, Ramesh VJ. Management of guillain-barré syndrome. J Neuroanaesthesiol Crit Care. 2019;6:160-6. doi:10.1055/s-0039-1688896.
2. Rosen BA. Guillain-Barré syndrome. Pediatrics in Review. 2012;33(4):164-70. doi:10.1542/pir.33-4-164.
3. Lawn ND, Fletcher DD, Henderson RD, Wolter TD, Wijddicks EF. Anticipating mechanical ventilation in guillain-barré syndrome. Arch Neurol. 2001;58(6):893-8. doi:10.1001/archneur.58.6.893.
4. Berg BV, Walgaard C, Drenthen J, Fokke C, Jacobs BC, Doorn PA. Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol. 2014;10:469-82. doi: 10.1038/nrneurol.2014.121.
5. Yuki N, Hartung HP. Guillain–Barré syndrome. N Engl J Med. 2012;366:2294–304. doi: 10.1056/NEJMra1114525.
6. Tam CC, Rodrigues LC, Petersen I, Islam A, Hayward A, O’Brien SJ. Incidence of Guillain–Barré syndrome among patients with campylobacter infection: a general practice research database study. J Infect Dis. 2006;194:95–7. doi: 10.1086/504294.
7. Goodfellow JA, Willison HJ. Guillain-Barré syndrome: a century of progress. Nat Rev Neurol. 2016;12(12):723–31. doi: 10.1038/nrneurol.2016.172.
8. Willison HJ, Jacobs BC, Doorn PA. Guillain-Barré syndrome. Lancet. 2016;388:717-27. doi: 10.1016/S0140-6736(16)00339-1.
9. Fokke C, Berg BV, Drenthen J, Walgaard C, Doorn PA, Jacobs BC. Diagnosis of Guillain-Barré syndrome and validation of brighton criteria. Brain. 2014;137:33-43.doi:10.1093/brain/awt285.
10. Sejvar JJ, Kohl KS, Gidudu J, Amato A, Bakshi N, Baxter R, et al. Guillain-Barre Syndrome and fisher syndrome: Case definitions and guidelines for collection, analysis, and presentation of immunization safety data. Vaccine. 2011;29:599-612.
11. Agrawal S, Peake D, Whitehouse WP. Management of children with Guillain-Barré syndrome. Arch Dis Child Educ Pract Ed. 2007;92(6):161-8. doi:10.1136/adc.2004.065706.
12. Lukito V, Mangunatmadja I, Pudjiadi AH, Puspandjono TM. Plasmaferesis sebagai terapi sindrom Guillain Barré berat pada anak. Sari Pediatri. 2010;11(6):450-1. doi: 10.14238/sp11.6.2010.448-55.
13. Alboudi AM, Sarathchandran P, Geblawi SS, Kayed DM, Inshasi J, Purayil SP, et al. Rescue treatment in patients with poorly responsive Guillain-Barré Syndrome. Sage Open Medicine. 2019;(7):1-5. doi: 10.1177/2050312119840195.
14. Verboon C, Doom PA, Jacobs BC. Treatment dilemmas in Guillain-Barré syndrome. J Neurol Neurosurg Psychiatry. 2016;88(4):346-52. doi:10.1136/jnnp-2016-314862.
15. Korinthenberg R, Schessl J, Kirschner J, Monting JS. Intravenously administered immunoglobulin in the treatment of childhood Guillain-Barré syndrome: a randomized trial. Pediatrics. 2005;116(1):8-14. doi: 10.1542/peds.2004-1324.
16. El-Bayoumi MA, El-Refaey AM, Abdelkader AM, El-Assmy MM, Alwakeel AA, El-Tahan HM. Comparison of intravenous immunoglobulin and plasma exchange in treatment of mechanically ventilated children with Guillain-Barré syndrome: a randomized study. Crit Care. 2011;15(4):R164. doi:10.1186/cc10305.
17. Kamate M, Detroja M, Reddy AN. Do all children with Guillain-Barre syndrome need immunotherapy? The Indian J of Ped. 2019. Doi: 10.1007/s12098-019-02864-0
18. Ortiz-Corredor F, Pena Preciado M. Use of immunoglobulin in severe childhood Guillain-Barre syndrome. Acta Neurol Scand. 2007;115:289-93. doi: 10.1111/j.1600-0404.2006.00766.x
19. Restrepo-Jimenez P, Rodríguez Y, González P, Chang C, Gershwin ME, Anaya JM. The immunotherapy of Guillain-Barré syndrome. Expert Opin Biol Ther. 2018;18(6):619-31. doi: 10.1080/14712598.2018.1468885.
20. Xiao J, Simard AR, Shi FD, Hao J. New strategies in the management of Guillain Barré syndrome. Clin Rev Allergy Immunol. 2014;47(3):274-88. doi: 10.1007/s12016-013-8388-5.
21. Lee JH, Sung IY, Rew IS. Clinical Presentation and prognosis of childhood Guillain Barre syndrome. J of Paed and Chil Health. 2008;44:449-54. doi : 10.1111/j.1440-1754.2008.01325.x
22. Korinthenberg R, Schessl J, Kirschner J. Clinical presentation and course of childhood Guillain Barré syndrome: a prospective multicentre study. Neuropediatrics. 2007;38(1):10-7. doi:10.1055/s-2007-981686
23. Vajsar J, Fehlings D, Stephens D. Longterm outcome in children with Guillain Barré syndrome. J Pediatr. 2003;142(3):305-9. doi: 10.1067/mpd.2003.115.
Unduhan
Diterbitkan
2019-12-23
Cara Mengutip
Reynaldo, G., & Desiree, A. (2019). Efektivitas Immunoterapi Dalam Tatalaksana Guillain-Barré Syndrome Pada Anak. Jurnal Kedokteran Meditek, 25(3), 107–114. https://doi.org/10.36452/jkdoktmeditek.v25i3.1783
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