High Intensity Focused Ultrasound: Terapi Non-Invasif Efektif untuk Hipertensi Resisten
DOI:
https://doi.org/10.36452/jkdoktmeditek.v26i1.1806Keywords:
HIFU, Resistant Hypertension, Renal DenervationAbstract
Resistant hypertension is defined as blood pressure (BP) remaining above therapy goal despite the use of three or more antihypertensive drugs at maximally tolerated doses (one ideally being a diuretic) or BP that requires four or more agents to reach the blood pressure therapy goal. One approach used to treat resistant hypertension is renal denervation. Various methods have been developed, from the resection, Radiofrequency Ablation (RFA) catheter, to High-Intensity Focused Ultrasound (HIFU). HIFU is the newest method and has promising efficacy. The results of test in animal and clinical trial in humans are showing a good outcome. Moreover, HIFU is a non-invasive procedure so that able to minimize the undesirable effect of invasive or surgical procedure. The only reported side effect of this procedure is back pain which can be cured with painkiller medications.
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18. Rong S, Zhu H, Liu D, Qian J, Zhou K, Zhu Q, et al. Noninvasive renal denervation for resistant hypertension using high-intensity focused ultrasound. Hypertension. 2015;66(4): 22–5.
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2. World Health Organization (WHO). Fact Sheets: Hypertension [Internet]. 2019. [Diakses pada 24 Desember 2019] Tersedia di https://www.who.int/news-room/fact-sheets/detail/hypertension
3. Badan Pusat Statistik. Penduduk Indonesia menurut Provinsi 1971, 1980, 1990, 1995, 2000 dan 2010 [Internet]. 2019. [Diakses pada 24 Desember 2019] Tersedia di https://www.bps.go.id/statictable/2009/02/20/1267/penduduk-indonesia-menurut-provinsi-1971-1980-1990-1995-2000-dan-2010.html2017
4. American Heart Association. 2017 Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults. J Am Coll Cardiol. Sep 2017;23976; DOI: 10.1016/j.jacc.2017.07.745
5. Ripley TL, Babato A. PSAP Book 1 Cardiology: Hypertension. New York: AACP;2018
6. Oparil S, Schmieder RE. New Approaches in the treatment of hypertension. Circ Res. 2015;116(6): 1074–95.
7. Alexander V V., Shi Z, Iftekher F, Welsh MJ, Gurm HS, Rising G, et al. Renal denervation using focused infrared fiber lasers: A potential treatment for hypertension. Lasers Surg Med. 2014;46(9): 689–702.
8. Freyhardt P, Heckmann L, Beck A, Stolzenburg N, Schnorr J, Kamp J, et al. MR-Guided high-focused ultrasound for renal sympathetic denervation - a feasibility study in pigs. J Ther Ultrasound. 2014;2(1): 1–10.
9. Esler MD, Böhm M, Sievert H, Rump CL, Schmieder RE, Krum H, et al. Catheter-based renal denervation for treatment of patients with treatment-resistant hypertension: 36 month results From The SYMPLICITY HTN-2 randomized clinical trial. Eur Heart J. 2014;35(26): 1752–9.
10. Chernin G, Szwarcfiter I, Bausback Y, Jonas M. Renal sympathetic denervation system via intraluminal ultrasonic ablation: Therapeutic intravascular ultrasound design and preclinical evaluation. J Vasc Interv Radiol. 2017;28(5): 740–8.
11. Wang Q, Guo R, Rong S, Yang G, Zhu Q, Jiang Y, et al. Noninvasive renal sympathetic denervation by extracorporeal high-intensity focused ultrasound in a pre-clinical canine model. J Am Coll Cardiol. 2013;61(21): 2185–92.
12. Pujasari A, Setyawan H, Udiyono A. Faktor–faktor internal ketidakpatuhan pengobatan hipertensi di puskesmas Kedungmundu Kota Semarang. J Kes Mas 2015;3(3): 99-108.
13. Judd E, Calhoun DA. Apparent and true and resistant hypertension: Definition, prevalence and outcomes. J Hum Hypertens. 2014;28(8): 463–8.
14. Giannattasio C, Cairo M, Cesana F, Alloni M, Sormani P, Colombo G et al. Blood pressure control in Italian essential hypertensives treated by general practitioners. Am J Hypertens 2012;25: 1182–7.
15. Sim JJ, Bhandari SK, Shi J, Liu IL, Calhoun DA, McGlynn EA et al. Characteristics of resistant hypertension in a large, ethnically diverse hypertension population of an integrated health system. Mayo Clin Proc 2013; 88: 1099–107.
16. Shea J, de Bever J, Kholmovski E, Beal H, Hadley JR, Minalga E, et al. Effect of applied energy in renal sympathetic denervation with magnetic resonance guided focused ultrasound in a porcine model. J Ther Ultrasound. 2017;5(1): 1–10.
17. Papademetriou V, Rashidi AA, Tsioufis C, Doumas M. Renal nerve ablation for resistant hypertension: How did we get here, present status, and future directions. Circulation. 2014;129(13): 1440–51.
18. Rong S, Zhu H, Liu D, Qian J, Zhou K, Zhu Q, et al. Noninvasive renal denervation for resistant hypertension using high-intensity focused ultrasound. Hypertension. 2015;66(4): 22–5.
19. Schmieder RE, Ott C, Bramlage P. Non-invasive renal denervation: Update on external ultrasound approaches. Curr Hypertens Rep [Internet]. 2016;18(6):1–7. Available from: http://dx.doi.org/10.1007/s11906-016-0653-6
20. Neuzil P, Ormiston J, Brinton TJ, Starek Z, Esler M, Dawood O, et al. Externally delivered focused ultrasound for renal denervation. JACC Cardiovasc Interv. 2016;9(12): 1292–9.
21. Yaxley JP, Thambar SV. Resistant hypertension: An approach to management in primary care. J Fam Med Prim Care. 2015;4(2): 193-9.
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Published
2020-03-30
How to Cite
Arisandi, R. (2020). High Intensity Focused Ultrasound: Terapi Non-Invasif Efektif untuk Hipertensi Resisten. Jurnal Kedokteran Meditek, 26(1), 31–35. https://doi.org/10.36452/jkdoktmeditek.v26i1.1806
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