Patofisiologi, Diagnosis, dan Tata Laksana Dermatosis Neutrofilik  yang Umum Ditemui

Hendra Wijaya Wong

doi:10.36452/jkdoktmeditek.v29i1.2340

Authors

Hendra Wijaya Wong Departemen Dermatologi dan Venereologi, Fakultas Kedokterandan Ilmu Kesehatan, Universitas Kristen Krida Wacana, Jakarta, Indonesia

DOI:

https://doi.org/10.36452/jkdoktmeditek.v29i1.2340

Keywords:

dermatosis neutrofilik, dermatosis pustular subkorneal, penyakit Behcet, pioderma gangrenosum, sindrom sweet

Abstract

Dermatosis neutrofilik adalah sebuah kelompok penyakit inflamasi kulit dengan predominasi infiltrat neutrofil yang steril dan memiliki manifestasi klinis yang berbeda-beda. Tertundanya diagnosis dan tatalaksana dapat menyebabkan morbiditas yang signifikan bahkan kematian. Tinjauan pustaka ini membahas manifestasi klinis, pemeriksaan penunjang, tata laksana, dan komplikasi dermatosis neutrofilik yang relatif umum ditemui, yaitu sindrom Sweet, pioderma gangrenosum, dermatosis pustular subkorneal, dan penyakit Behcet. Pilihan terapi umumnya bersifat imunosupresif dan perlu disesuaikan dengan diagnosis; pada kebanyakan kasus, kortikosteroid adalah terapi lini pertama diikuti agen imunosupresan lainnya seperti kolkisin dan siklosporin sampai agen biologik yang memiliki target spesifik. Pengenalan akan gambaran klinis dan tatalaksana yang adekuat wajib dimiliki oleh dokter spesialis dermatologi dan venereologi untuk menegakkan diagnosis sedini mungkin dan mencegah komplikasi.

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