Lupus Eritematosus Sistemik pada Anak

Nicodemus

doi:10.36452/jkdoktmeditek.v30i1.2611

Authors

Nicodemus Pediatric Intensive Care Unit, Mayapada Hospital, Jakarta Selatan, Indonesia

DOI:

https://doi.org/10.36452/jkdoktmeditek.v30i1.2611

Keywords:

Autoimun, cSLE, LES, lupus, onset anak

Abstract

Lupus eritematosus sistemik merupakan penyakit yang tidak saja menyerang dewasa tetapi sering kali ditemukan pada anak dengan onset dini. Penyakit ini dapat menyerupai berbagai penyakit lain dengan gejala yang tidak spesifik sehingga penegakkan diagnosis sulit dilakukan. Etiologi dan patogenesis dari LES juga masih belum diketahui secara pasti. Tujuan dari karya tulis ini adalah untuk menambah pengetahuan klinisi mengenai lupus pada anak sehingga mampu melakukan penegakkan diagnosis lebih dini agar dapat memberikan tata laksana yang adekuat. Dengan diagnosis dini dan tata laksana yang adekuat, diharapkan mampu memperbaiki kualitas hidup pasien dan mencegah terjadinya komplikasi dari lupus.

References

Smith EMD, Lythgoe H, Midgley A, Beresford MW, Hedrich CM. Juvenile-onset systemic lupus erythematosus: update on clinical presentation, pathophysiology and treatment options. Clin Immunol. 2019;209:108274

Tarr T, Dérfalvi B, Gyo˝ri N, Szántó A, Siminszky Z, Malik A, et al. Similarities and differences between pediatric and adult patients with systemic lupus erythematosus. Lupus 2015;24:796-803.

Farkhati MY, Hapsara S, Satria CD. Antibodi anti DS-DNA sebagai faktor prognosis mortalitas pada lupus erimatosus sistemik. Sari Pediatr. 2016;14:90.

Levy DM, Kamphuis S. Systemic lupus erythematosus in children and adolescents. Pediatr Clin North Am 2012;59:345-64.

Harry O, Yasin S, Brunner H. Childhood-onset systemic lupus erythematosus: a review and update. J Pediatr 2018;196:22-30.e2.

Massias, JS, Smith, EMD, Al-Abadi, E, Armon, K, Bailey, K, Ciurtin, C, et al. Clinical and laboratory characteristics in juvenile-onset systemic lupus erythematosus across age groups. Lupus 2020; 29: 474–481

Lim, SC, Chan, EWL, Tang, SP. Clinical features, disease activity and outcomes of Malaysian children with paediatric systemic lupus erythematosus: A cohort from a tertiary centre. Lupus 2020; 29: 1106–1114

Sari, MK, Satria CD, Arguni E. Predictors of infection in children with systemic lupus erythematosus: a single center study in Indonesia. Glob Pediatr Health 2021; 9;8:2333794X211005609.

Fonseca R, Aguiar F, Rodrigues M, Brito I. Clinical phenotype and outcome in lupus according to age: a comparison between juvenile and adult onset. Reumatol Clin. 2018;14(3):160–3.

Massias JS, Smith EMD, Al-Abadi E, Armon K, Bailey K, Ciurtin C, et al. Clinical and laboratory characteristics in juvenile-onset systemic lupus erythematosus across age groups. Lupus. 2020;29(5):474–81.

Massias JS, Smith EMD, Al-Abadi E, Armon K, Bailey K, Ciurtin C, et al. Clinical and laboratory phenotypes in juvenile-onset systemic lupus erythematosus across ethnicities in the UK. Lupus. 2020;in press

Lewandowski L, Scott C, Gomez-Martin D, Silverman ED, Aksentijevich I, Deng Z, et al. GG-10 Imagine SLE: international multi-site assessment of genetics and inflammation in early onset and familial systemic lupus erythematosus. Lupus Sci Med 2016;3.

Hedrich CM, Smith EMD, Beresford MW. Juvenile-onset systemic lupus erythematosus (jSLE) – pathophysiological concepts and treatment options. Best Pract Res Clin Rheumatol. 2017;31(4): 488–504.

Pereira KM, Faria AG, Liphaus BL, Jesus AA, Silva CA, CarneiroSampaio M, et al. Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus. Rheumatology 2016;55:869-73.

Trindade VC, Carneiro-Sampaio M, Bonfa E, Silva CA. AN update on the management of childhood-onset systemic lupus erythematosus. Pediatr Drugs 2021; 23:331-47

Singla S, Wenderfer SE, Muscal E, Sagcal-Gironella ACP, Orange JS, Makedonas G. Changes in frequency and activation status of major CD4+ T-cell subsets after initiation of immunosuppressive therapy in a patient with new diagnosis childhoodonset systemic lupus erythematosus. Front Pediatr. 2017. https:// doi.org/10.3389/fped.2017.00104

Smith EMD, Lythgoe H, Midgley A, Beresford MW, Hedrich CM. Juvenile-onset systemic lupus erythematosus: update on clinical presentation, pathophysiology and treatment options. Clin Immunol. 2019; 209:108274.

Doaty S, Agrawal H, Bauer E, Furst DE. Infection and lupus: which causes which? Curr Rheumatol Rep 2016;18:13.

Lee MH, Sriram U, Chakhtoura M, Chain RW, Caricchio R, Gallucci S. The effects of estrogen on the IFN signature in lupus. J Immunol 2016;196:118.

Munroe ME, Lu R, Zhao YD, Fife DA, Robertson JM, Guthridge JM, et al. Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification. Ann Rheum Dis 2016;75:2014-21

Harry O, Yasin S, Brunner H. Childhood-onset systemic lupus erythematosus: a review and update. J Pediatr 2018; 196:22-30.e2.

Silva CA. Childhood-onset systemic lupus erythematosus: early disease manifestations that the paediatrician must know. Expert Rev Clin Immunol 2016;12:907-10.

Gomes RC, Silva MF, Kozu K, Bonfá E, Pereira RM, Terreri MT, et al. Features of 847 childhood-onset systemic lupus erythematosus patients in three age groups at diagnosis: a Brazilian multicenter study. Arthritis Care Res (Hoboken) 2016;68:1736-41.

Ruano CA, Malheiro R, Oliveira JF, Pinheiro S, Vieira LS, MoraesFontes MF. Ultrasound detects subclinical joint inflammation in the hands and wrists of patients with systemic lupus erythematosus without musculoskeletal symptoms. Lupus Sci Med 2017;4:e000184

Bert J, Gertner E. Lupus gastrointestinal tract vasculopathy: lupus “enteritis”involving the entire gastrointestinal tract from esophagus to rectum. Case Rep Gastroenterol 2017;11:48-53.

Weiss JE. Pediatric systemic lupus erythematosus: more than a positive antinuclear antibody. Pediatr Rev 2012;33:62-73.

Wenderfer SE, Ruth NM, Brunner HI. Advances in the care of children with lupus nephritis. Pediatr Res 2017;81:406-14.

Karuniawaty TP, SUmadiono, Satria CD. Perbandingan diagnosis systemic lupus erythematosus menggunakan kriteria American College of Rheumatology dan Systemic Lupus International Colleaborating Clinics. Sari Pediatri 2016; 18:4.

Aljaberi N, Nguyen K, Strahle C, Merritt A, Mathur A, Brunner HI. The Performance of the New 2019-EULAR/ACR Classifcation Criteria for Systemic Lupus Erythematosus in Children and Young Adults. Arthritis Care Res 2019; 18:1151-1159.

Ma M, Hui-Yuen JS, Cerise JE, Iqbal S, Eberhard BA. Validation of the 2019 European league against Rheumatism/ American College of Rheumatology Criteria Compared to the 1997 American College of Rheumatology Criteria and the 2012 Systemic Lupus International Collaborating Clinics Criteria in Pediatric Systemic Lupus Erythematosus. Arthritis Care Res. 2020;72:1597–601.

Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, et al. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann 344 V. C. Trindade et al. Rheum Dis. 2019;78:1151–9.

Jordan N, D’Cruz D. Current and emerging treatment options in the management of lupus. Immunotargets Ther 2016;5:9-20.

Rodsaward P, Chottawornsak N, Suwanchote S, Rachayon M, Deekajorndech T, Wright HL, Edwards SW, Beresford MW, Rerknimitr P, Chiewchengchol D. The clinical signifcance of antinuclear antibodies and specifc autoantibodies in juvenile and adult systemic lupus erythematosus patients. Asian Pac J Allergy Immunol. 2019. https://doi.org/10.12932/AP-211218-0465. Epub ahead of print. PMID: 31012595.

Ponticelli C, Moroni G. Hydroxychloroquine in systemic lupus erythematosus (SLE). Expert Opin Drug Saf. 2017;16:411–9.

Jongvilaikasem P, Rianthavorn P. Longitudinal growth patterns and fnal height in childhood-onset systemic lupus erythematosus. Eur J Pediatr. 2021;180:1431–41. https://doi.org/10.1007/ s00431-020-03910-2.

Pons-Estel BA, Bonfa E, Soriano ER, Cardiel MH, Izcovich A, Popof F, et al. First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)-Pan-American League of Associations of Rheumatology (PAN. Ann Rheum Dis. 2018;77:1549–57.

Groot N, De Graef N, Marks SD, Brogan P, Avcin T, BaderMeunier B, et al. European evidence-based recommendations for the diagnosis and treatment of childhood-onset lupus nephritis: The SHARE initiative. Ann Rheum Dis. 2017;76:1965–73.

Correll CK, Miller DD, Maguiness SM. Treatment of childhoodonset lupus erythematosus panniculitis with Rituximab. JAMA Dermatol. 2020;156:566–9.

Mahmoud I, Jellouli M, Boukhris I, Charfi R, Ben Tekaya A, Saidane O, et al. Efficacy and safety of rituximab in the management of pediatric systemic lupus erythematosus: a systematic review. J Pediatr 2017;187:213- 9,e2.

Rodriguez-Smith J, Brunner HI. Update on the treatment and outcome of systemic lupus erythematous in children. Curr Opin Rheumatol. 2019;31:464–70.

Brunner HI, Abud-Mendoza C, Viola DO, Calvo Penades I, Levy D, Anton J, et al. Safety and efcacy of intravenous belimumab in children with systemic lupus erythematosus: results from a randomised, placebo-controlled trial. Ann Rheum Dis. 2020;79:1340–8.

Mok CC. Calcineurin inhibitors in systemic lupus erythematosus. Best Pract Res Clin Rheumatol. 2017;31:429–38.

Balbi GGM, MacHado-Ribeiro F, Marques CDL, Signorellia F, Levy RA. The interplay between tuberculosis and systemic lupus erythematosus. Curr Opin Rheumatol. 2018;30:395-402.

Listiyono F, Sumadiono, Dewi Satria C, Murni IK. Predictors of mortality in children with systemic lupus erythematosus. Paediatr Indones. 2019;59:1-6.

Jung JY, Yoon D, Choi Y, Kim HA, Suh CH. Associated clinical factors for serious infections in patients with systemic lupus erythematosus. Sci Rep. 2019;9:1-8. doi:10 .1038/s41598-019-46039-5

Parodis I, Tamirou F, Houssiau FA. Prediction of prognosis and renal outcome in lupus nephritis. Lupus Sci Med. 2020;7:e000389.

Mahajan A, Amelio J, Gairy K, Kaur G, Levy RA, Roth D, et al. Systemic lupus erythematosus, lupus nephritis and end-stage renal disease: a pragmatic review mapping disease severity and progression. Lupus. 2020;29:1011–20.

Brunner HI, Gulati G, Klein-Gitelman MS, Rouster-Stevens KA, Tucker L, Ardoin SP, et al. Urine biomarkers of chronic kidney damage and renal functional decline in childhood-onset systemic lupus erythematosus. Pediatr Nephrol. 2019;34:117–28.