Perbandingan Penanda Inflamasi dan Elastisitas Vaskular antara Mahasiswa Kedokteran Prehipertensi dan Normotensi di Jakarta

Naufal Rafi Kusuma  Wibowo; Nurfitri Bustamam; Meiskha  Bahar; Diana Agustini  Purwaningastuti

doi:10.36452/jkdoktmeditek.v31i2.3539

Authors

Naufal Rafi Kusuma Wibowo Universitas Pembangunan Nasional Veteran, Jakarta, Indonesia
Nurfitri Bustamam Universitas Pembangunan Nasional Veteran, Jakarta, Indonesia
Meiskha Bahar Universitas Pembangunan Nasional Veteran, Jakarta, Indonesia
Diana Agustini Purwaningastuti Universitas Pembangunan Nasional Veteran, Jakarta, Indonesia

DOI:

https://doi.org/10.36452/jkdoktmeditek.v31i2.3539

Keywords:

inflammation, prehypertension, risk factors, young adult

Abstract

Introduction: An unhealthy lifestyle among medical students may
contribute to inflammation, reduced vascular elasticity, and
increased blood pressure. However, cardiovascular risk in these
young adults remains less explored compared to hypertensive
patients. Purpose: This study compares inflammatory markers and
vascular elasticity in prehypertensive and normotensive medical
students. Methods: A case-control study utilizing simple random
sampling was conducted in the medical student population, included
54 prehypertensive or normotensive subjects with no history of
hematological disorders, autoimmune diseases, cancer, diabetes
mellitus, or cardiovascular medication use. Vascular elasticity,
blood pressure, and inflammatory markers were assessed using an
accelerated photoplethysmograph, a digital sphygmomanometer,
and a hematology analyzer. Results: A total of 25 subjects (46.3 %)
had suboptimal vascular elasticity, 30 (55.6%) had a high
neutrophil-to-lymphocyte ratio (NLR), and 40 (74.1%) exhibited a
low-risk platelet-to-lymphocyte ratio (PLR). The Chi-square test
revealed a significant difference in NLR between prehypertensive
and normotensive students (p = 0.000; OR = 7.0; CI = 2.3–20.7),
while no significant difference was observed in PLR (p = 0.525).
Vascular elasticity also differed significantly between groups (p =
0.000; OR = 5.2; CI = 2.0-13.2). Conclusion: Prehypertensive
subjects had higher NLR, and those with suboptimal vascular
elasticity had higher prehypertension risk. These findings highlight
the need for cardiovascular risk assessment in young adults.

Author Biographies

Nurfitri Bustamam, Universitas Pembangunan Nasional Veteran, Jakarta, Indonesia

Departemen Fisiologi, Fakultas Kedokteran

Meiskha Bahar, Universitas Pembangunan Nasional Veteran, Jakarta, Indonesia

Departemen Mikrobiologi, Fakultas Kedokteran

Diana Agustini Purwaningastuti, Universitas Pembangunan Nasional Veteran, Jakarta, Indonesia

Departemen Anatomi, Fakultas Kedokteran

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